Fig. 5
From: Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents
Cytotoxic effect of compounds 7a-e, 8a-c and 10a-k on MCF-7, Hela and A549 cell lines Taken to gather, regarding the cytotoxic evaluations on 7a-e and 8a-c derivatives, it can be realizing that 7e was the most potent derivative against all three tested cell lines. The structure activity relationship disclosed that electronegative substitution such as Cl and Br at para position of phenyl ring (X1) and also, the presence of phenyl ring at R position could increase the inhibitory activity significantly in a 7a-e series. Also, the presence of one-carbonyl group showed necessary for pharmacological effect. In addition, propane-1-yl-derivatives (8a-c) had least effect on cytotoxic activity. In the case of 10a-k, replacement of H with Ph moiety at R position led to decreased cytotoxic activity (10f-k) and also, no substituted analogue (10a) had favorable pharmacological effect on MCF-7 and Hela cell lines. The cytotoxicity of all synthesized compounds were shown in Table 1.