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Table 1 α-Glucosidase inhibitory activity of compounds 7a–r

From: Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors

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Compounds

R

IC50 (µM)a

Concentrations of precipitation (µM)

7a

363.4 ± 1.1

 > 150

7b

14.4 ± 0.2

 > 150

7c

255.5 ± 1.7

 > 150

7d

692.5 ± 2.4

 > 150

7e

114.3 ± 1.8

 > 150

7f

25.6 ± 1.0

 > 150

7g

332.9 ± 3.1

 > 150

7h

454.83 ± 1.8

 > 150

7i

326.2 ± 2.3

 > 150

7j

715.4 ± 1.8

 > 150

7k

529.6 ± 0.6

 > 150

7l

 > 750

 > 150

7m

 > 750

 > 150

7n

 > 750

 > 150

7o

 > 750

 > 150

7p

 > 750

 > 150

7q

 > 750

 > 150

7r

595.0 ± 3.1

 > 150

Acarboseb

 

750.0 ± 1.6

 
  1. aData presented here are the mean ± S.E of three independent experiments
  2. bPositive control