Table 1 Structures and IC50 values (µM) of compounds 4a–m against yeast α-glucosidase
| |||||
|---|---|---|---|---|---|
Compound | R | IC50 (µM)a | Compound | R | IC50 (µM)a |
4a | H | 118.0 ± 3.1 | 4h | 4-F | 474.9 ± 2.6 |
4b | 4-CH3 | 167.5 ± 0.8 | 4i | 3-Cl | > 750 |
4c | 4-OCH3 | 170.2 ± 2.1 | 4j | 4-Cl | 229.7 ± 2.3 |
4d | 3-Phenoxy | 116.0 ± 0.7 | 4k | 3-Br | > 750 |
4e | 3-OH | > 750 | 4l | 2-NO2 | > 750 |
4f | 4-OH | > 750 | 4m | 3-NO2 | 180.5 ± 1.4 |
4g | 3-F | 174.0 ± 2.3 | Acarbose | – | 750.0 ± 5.0 |
