Fig. 1

Rationale for the design of coumarin-indole hybrids as the new α-glucosidase inhibitors. Therefore, based on anti-α-glucosidase agents containing coumarin (compounds A–C), biscoumarin (compounds D–E), indole (compounds F–H), or bisindole (compounds I–J), we considered coumarin-indole hybrids as new α-glucosidase inhibitors. These compounds after synthesis, evaluated against α-glucosidase in vitro and in silico