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Table 9 Effect of compound 4c at different concentrations on HepG2 cell cycle progression after 48 h of incubation

From: Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Concentration

HepG2

Sub-G1

G0/G1

S

G2/M

2 µM

29.58 ± 1.66

31.00 ± 1.74

26.75 ± 0.94

9.75 ± 0.77

5 µM

39.55 ± 1.28**

27.77 ± 1.06

25.04 ± 0.43

8.9 ± 1.15

10 µM

42.99 ± 1.09***

24.69 ± 1.14**

24.13 ± 0.66*

8.23 ± 0.89*

Control/vehicle

32.79 ± 0.66

32.00 ± 1.01

27.49 ± 0.58

10.98 ± 0.18

  1. The data presented are the mean ± SEM of three independent experiments *p < 0.05, **p < 0.01, ***p < 0.001 compared with control/vehicle
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BMC Chemistry

ISSN: 2661-801X

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