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Table 5 Percentage of HT-29 cells in each state after treatment with compound 4e at 48 h

From: Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Concentration

Vital (%) An −/PI −

Early apoptosis (%) An +/PI −

Late apoptosis (%) An +/PI +

Necrosis (%) An −/PI +

6 µM

97.18 ± 0.22

1.64 ± 0.16

0.35 ± 0.01

0.61 ± 0.0

10 µM

96.75 ± 0.18*

2.46 ± 0.26**

0.36 ± 0.04

0.24 ± 0.01

15 µM

95.99 ± 0.56***

3.82 ± 0.51****

0.41 ± 0.03*

0.28 ± 0.05

Control/vehicle

97.98 ± 0.1

0.99 ± 0.08

0.29 ± 0.02

0.58 ± 0.03

  1. The data presented are the mean ± SEM of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001and ****p < 0.0001 compared with control/vehicle
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BMC Chemistry

ISSN: 2661-801X

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