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Table 4 Percentage of HT-29 cells in each state after treatment with compound 4c at 48 h

From: Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Concentration

Vital (%) An −/PI −

Early apoptosis (%) An +/PI −

Late apoptosis (%) An +/PI +

Necrosis (%) An −/PI + 

6 µM

92.25 ± 0.79

3.49 ± 0.53***

1.52 ± 0.02****

1.19 ± 0.11

10 µM

92.20 ± 1.64

3.96 ± 0.43***

1.53 ± 0.18****

1.64 ± 0.095

15 µM

90.26 ± 0.98

5.78 ± 0.46****

2.46 ± 0.13****

1.93 ± 0.23

Control/vehicle

97.98 ± 0.1

0.08 ± 0.99

0.29 ± 0.02

0.58 ± 0.03

  1. The data presented are the mean ± SEM of three independent experiments. ***p < 0.001, ****p < 0.001 compared with control/vehicle