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Table 5 Statistical comparison of the developed potentiometric method to the reported HPLC method for determination of OND in Zofran® tablets form and plasma sample

From: Experimentally designed electrochemical sensor for therapeutic drug monitoring of Ondansetron co-administered with chemotherapeutic drugs

Parameter

Zofran® Tablet

Spiked human plasma samples

Developed potentiometric method

Reporteda HPLC method

Developed potentiometric method

Reporteda HPLC method (41)

Mean

100.01

100.84

98.26

98.67

SD

1.082

0.86

2.227

2.875

Variance

1.171

0.740

4.960

8.266

n

6

6

6

6

Student’s t-testb

1.471 (2.228)b

0.276 (2.228)b

F valueb

1.583 (7.146)b

1.667 (7.146)b

  1. aHPLC method using C18 column as the stationary phase and a mixture consisting of acetonitrile: 0.02 M sodium phosphate monobasic buffer (pH adjusted to 3.0 using phosphoric acid) in ratio (60:40, v/v) as a mobile phase. The mobile phase was pumped at a flowrate of 1.5 ml/min. UV detection was carried out at 305.0 nm[41]
  2. bValues in parentheses are the corresponding tabulated two-tailed values at significance level α = 0.05