Experimentally designed electrochemical sensor for therapeutic drug monitoring of Ondansetron co-administered with chemotherapeutic drugs

Table 1 The custom experimental design architecture for the levels and components of the studied sensors and the observed responses for each sensor

Sensor no	Factor 1		Factor 2		Factor 3		Response 1	Response 2	Response 3	Response 4
Sensor no	Plasticizer		Ion exchanger		Ionophore		Slope	r	pLOQ	\(\mathrm{log}{K}_{OND, {Na}^{+}}^{pot}\)
1	−1	NPOE	2	RK	−2	BCD	53.55	0.9984	4.57	−2.50
2	1	DOP	2	RK	−1	HPBCD	53.10	0.9992	4.57	−3.71
3	−1	NPOE	−1	PT	−1	HPBCD	62.79	0.9983	4.36	−4.22
4	−1	NPOE	1	TKS	1	CX4	59.70	0.9972	5.32	−2.96
5	1	DOP	−1	PT	0	CMBCD	62.56	0.9986	4.79	−3.44
6	1	DOP	1	TKS	2	CX8	56.49	0.9976	5.03	−3.56
7	−1	NPOE	0	PM	−1	HPBCD	59.05	0.9980	4.01	−4.23
8	−1	NPOE	−2	TPB	2	CX8	59.05	0.9965	4.57	−2.11
9	−1	NPOE	−1	PT	−2	BCD	66.41	0.9988	5.04	−2.88
10	1	DOP	−1	TPB	−2	BCD	60.78	0.9960	5.04	−2.86
11	−1	NPOE	2	RK	2	CX8	59.05	0.9981	4.57	−2.96
12	−1	NPOE	0	PM	0	CMBCD	56.04	0.9994	4.52	−3.12
13	−1	NPOE	1	TKS	0	CMBCD	60.15	0.9980	5.04	−2.94
14	−1	NPOE	−2	TPB	1	CX4	66.75	0.9971	5.32	−2.25
15	1	DOP	0	PM	1	CX4	50.25	0.9986	4.97	−3.26

ISSN: 2661-801X