Smart stability indicating spectrophotometric methods for determination of modafinil: the promising treatment for post-covid neurological syndrome

Table 1 Assay validation sheet of the proposed methods for the determination of pure samples of modafinil

Parameter	RD	¹DD	MCR	RS
Accuracy (mean ± SD)	99.97 ± 0.305	100.10 ± 0.560	100.02 ± 0.483	99.18 ± 0.1.145
Precision (RSD %)
Repeatability^*	0.764	1.104	1.008	0.939
Intermediate precision^**	0.855	0.958	0.952	1.112
Linearity
Slope	0.0362	0.1525	0.1812	0.0032
Intercept	0.1292	0.2614	0.235	0.0002
Correlation coefficient (r)	0.9999	0.9999	0.9999	0.9998
Range	(5-30 µg/mL)	(5-30 µg/mL)	(5-30 µg/mL)	(5-30 µg/mL)
Limit of quantification (µg/mL)	0.707	0.877	1.094	1.389
Limit of detection (μg/mL)	0.233	0.290	0.36	0.458
Robustness (RSD %)^***
[chosen wavelength ± 2 nm]	1.737	0.689	0.779	1.103

^*The intra-day (n = 3), RSD of three concentration 20, 25, 30 µg/mL of MDF triplicate analysis within the day and
^**The inter-day (n = 3), RSD of three concentration 20, 25, 30 µg/mL of MDF triplicate analysis/day on three successive days by the suggested spectrophotometric methods
^***RSD of MDF concentration of 15 µg/mL -repeatedly 3 times- were determined under minor wavelength variation [chosen wavelength for each method ± 2 nm]

ISSN: 2661-801X