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Table 6 Statistical comparison of the results obtained by the proposed spectrophotometric methods and the reported HPLC method for the determination of ternary mixture in Excedrin® PM Headache caplets

From: Eco-friendly resolution of spectrally overlapping signals of a combined triple-action over-the-counter pharmaceutical formulation for symptomatic management of COVID-19 pandemic: application to content uniformity testing

Parameters

Proposed methods

Reported method [10]a

PAR

ASP

DIPH

PAR

ASP

DIPH

Mean

100.55

100.47

100.16

99.46

100.15

99.07

SD

1.320

1.507

1.225

1.919

1.751

1.028

n

5

5

5

5

5

5

Variance

1.741

2.271

1.501

3.682

3.066

1.056

Student’s t-test (2.306)b

1.046

0.309

1.525

F value (6.39)b

2.11

1.35

1.42

  1. aHPLC-DAD method was performed using on XTerra C18 column with isocratic elution of mobile phase 0.1% triethylamine acidified water: methanol (70:30, v/v) adjusted with o-phosphoric acid to pH 3.0 and methanol (90:10, v/v) with flow rate programming and detection at 210.0 nm
  2. bTabulated t- and F values at P = 0.05