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Table 4 Results of content uniformity testing of PAR, ASP and DIPH in Excedrin® PM Headache caplets using the proposed spectrophotometric methods

From: Eco-friendly resolution of spectrally overlapping signals of a combined triple-action over-the-counter pharmaceutical formulation for symptomatic management of COVID-19 pandemic: application to content uniformity testing

Excedrin® PM Headache caplet No.

% Recovery of the labeled claim

PAR

D1 method

ASP

DWRS method

DIPH

DD-RD method

1

100.21

99.20

104.46

2

99.21

98.83

101.57

3

99.71

100.88

101.75

4

100.59

99.46

102.10

5

101.85

98.67

101.57

6

102.60

102.00

99.41

7

102.96

101.47

98.68

8

103.23

100.80

101.57

9

99.14

101.58

99.41

10

100.59

99.57

100.61

Mean

101.01

100.24

101.11

SD

1.541

1.234

1.672

%RSD

1.526

1.231

1.654

Acceptance value (AV) a

3.70

2.95

4.01

  1. aMaximum allowed Acceptance value (L1) = 15