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Table 9 Result of analysis of proposed method in human plasma

From: Quality by design approach for development and validation of a RP-HPLC method for simultaneous estimation of xipamide and valsartan in human plasma

Parameters

XIP

VAL

Taken µg/mL

Found µg/mL

Recoverya %

Accuracy (RE %)

Taken µg/mL

Found µg/mL

Recoverya %

Accuracy (RE %)

 

20

18.77

93.85

−6.14

20

17.73

88.65

−11.34

 

15

14.58

97.24

−2.75

15

12.96

86.44

−13.55

 

5

5.00

100.07

0.07

5

4.97

99.47

−0.52

 

2.5

2.03

81.2

−18.79

2.5

2.05

82.12

−17.87

Mean

  

93.09

−6.9

  

89.17

−10.82

 ± SD

  

8.32

   

7.38

 

 ± CV (%)

  

8.94

   

8.27

 

 ± SE

  

3.72

   

3.3

 

Variance

  

69.3

   

54.47

 
  1. aAverage of three determinations