Table 2 Central composite design for optimization with the measured responses
Std. | Run | Factor 1 | Factor 2 | Response 1 | Response 2 |
|---|---|---|---|---|---|
A: % MeOH | B: Flow rate (mL/min) | Retention time (VAL) (min) | Resolution | ||
12 | 1 | 62.5 | 1.1 | 5.99 | 6.23 |
6 | 2 | 66.0355 | 1.1 | 4.6 | 4.18 |
4 | 3 | 65 | 1.2 | 4.57 | 4.77 |
11 | 4 | 62.5 | 1.1 | 5.87 | 6.2 |
3 | 5 | 60 | 1.2 | 6.6 | 7.29 |
1 | 6 | 60 | 1 | 8 | 7.81 |
13 | 7 | 62.5 | 1.1 | 5.79 | 6.11 |
10 | 8 | 62.5 | 1.1 | 5.79 | 6.16 |
5 | 9 | 58.9645 | 1.1 | 7.68 | 8.48 |
9 | 10 | 62.5 | 1.1 | 5.76 | 6.16 |
8 | 11 | 62.5 | 1.24142 | 5.17 | 6.09 |
2 | 12 | 65 | 1 | 5.45 | 4.75 |
7 | 13 | 62.5 | 0.958579 | 6.6 | 6.27 |