Table 2 Accuracy and precision for the analysis of CAB in human plasma samples
LLOQ 2 pg/mL | Low QC 6 pg/mL | Med QC (A) 20 pg/mL | Med QC (B) 60 pg/mL | High QC 160 pg/mL | |
|---|---|---|---|---|---|
Day 1 intra-day accuracy (N = 6) | |||||
Equation (1/X) | Y = 1.299784 X − 0.017059 (R2 = 0.9978) | ||||
STD | 0.098 | 0.389 | 0.423 | 2.350 | 2.535 |
CV% | 4.67 | 6.77 | 2.02 | 3.75 | 1.59 |
Accuracy% | 105.38% | 95.88% | 104.64% | 104.42% | 99.71% |
Day 2 intra-day accuracy (N = 6) | |||||
Equation (1/X) | Y = 1.078651X − 0.030379 (R2 = 0.9968) | ||||
STD | 0.225 | 0.123 | 0.263 | 2.203 | 7.607 |
CV% | 11.917 | 2.118 | 1.400 | 3.737 | 4.941 |
Accuracy% | 94.31 | 97.15 | 93.75 | 98.24 | 96.22 |
Day 3 inter-day results (N = 18) | |||||
Equation (1/X) | Y = 1.238189*X + 0.027894 (R2 = 0.9944) | ||||
STD | 0.219 | 0.472 | 1.176 | 3.082 | 5.248 |
CV% | 11.107 | 8.054 | 5.792 | 5.119 | 3.326 |
Accuracy% | 98.46% | 97.63% | 101.54% | 100.35% | 98.60% |