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Table 2 In vitro antimicrobial activity of the synthesized compounds

From: Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents

Comp.

Antimicrobial screening (MIC = µM)

SA

BS

EC

ST

CA

AN

H1

32.7

32.7

65.4

32.7

32.7

32.7

H2

77.8

38.9

38.9

38.9

38.9

38.9

H3

62.9

15.7

31.4

31.4

31.4

15.7

H4

30.0

15.0

60.0

15.0

30.0

30.0

H5

13.2

26.3

52.7

26.3

26.3

26.3

H6

32.3

32.3

32.3

32.3

32.3

32.3

H7

31.5

15.8

63.1

31.5

31.5

31.5

H8

63.1

31.5

63.1

31.5

31.5

31.5

H9

60.9

30.5

60.9

30.5

30.5

30.5

H10

60.9

15.2

60.9

30.5

30.5

30.5

H11

31.2

31.2

15.6

15.6

31.2

31.2

H12

54.2

27.1

54.2

13.5

27.1

27.1

H13

29.2

29.2

58.5

29.2

29.2

7.3

H14

27.1

27.1

54.1

27.1

27.1

13.5

H15

15.2

30.3

15.2

15.2

30.3

30.3

H16

30.3

30.3

60.6

30.3

30.3

15.2

H17

15.2

30.3

30.3

30.3

30.3

30.3

H18

15.6

7.8

31.2

7.8

31.2

7.8

H19

58.5

29.2

58.5

29.2

29.2

29.2

Cefadroxil

34.4

34.4

17.2

34.4

–

–

Fluconazole

–

–

–

–

40.8

40.8

  1. SA: Staphylococcus aureus, BS: Bacillus subtilis, EC: Escherichia coli, ST: Salmonella typhi; CA: Candida albicans, AN: Aspergillus niger