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Fig. 4 | BMC Chemistry

Fig. 4

From: Design, synthesis, anticancer evaluation and docking studies of novel 2-(1-isonicotinoyl-3-phenyl-1H-pyrazol-4-yl)-3-phenylthiazolidin-4-one derivatives as Aurora-A kinase inhibitors

Fig. 4

a Overlay of compound P-6 (orange) with Aurora-A co-crystallized ligand (Pdb-2bmc). b Docked surface of ligand P-6 with Aurora-A complex. c Surface model structure of compound P-6 with Aurora A complex. d 2D ligand interaction diagram of compound P-6 with Aurora-A using Discovery Studio program with essential amino acid residues at the binding site are tagged in circles. The purple circles show the amino acids which participate in hydrogen bonding, and electrostatic or polar interactions and the green circles show the amino acids which participate in the Vander Waals interactions

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BMC Chemistry

ISSN: 2661-801X

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