Compounds | R | IC50 (µM) a,b |
---|---|---|
7a | C6H5 | 154.8 ± 3.0 |
7b | 2–NO2–C6H4 | 175.0 ± 5.9 |
7c | 3–NO2–C6H4 | 278.6 ± 5.8 |
7d | 4–NO2–C6H4 | 239.7 ± 7.5 |
7e | 3–F–C6H4 | 110.6 ± 6.0 |
7f | 4–Cl–C6H4 | 260.3 ± 4.5 |
7g | 4–OMe–C6H4 | 319.7 ± 4.9 |
7h | 2–NO2–3–OMe–C6H3 | 305.5 ± 7.2 |
7i | 2–Cl–5–NO2–C6H3 | 230.8 ± 5.5 |
7j | 3–OMe–4–OH–C6H3 | 358.2 ± 6.1 |
7k | 3,4,5–trimethoxy–C6H2 | > 750 |
7l | 3–OPh–C6H4 | 453.0 ± 4.7 |
7m | 5-Nitrobenzo[d][1,3]dioxole | 353.7 ± 3.5 |
7n | Naphthyl | 388.1 ± 6.5 |
7o | Thiophene | 145.4 ± 5.0 |
Acarbose | – | 750.0 ± 10.5 |