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Table 1 In vitro α-glucosidase inhibitory activities of compounds 7a–o

From: Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors

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Compounds

R

IC50 (µM) a,b

7a

C6H5

154.8 ± 3.0

7b

2–NO2–C6H4

175.0 ± 5.9

7c

3–NO2–C6H4

278.6 ± 5.8

7d

4–NO2–C6H4

239.7 ± 7.5

7e

3–F–C6H4

110.6 ± 6.0

7f

4–Cl–C6H4

260.3 ± 4.5

7g

4–OMe–C6H4

319.7 ± 4.9

7h

2–NO2–3–OMe–C6H3

305.5 ± 7.2

7i

2–Cl–5–NO2–C6H3

230.8 ± 5.5

7j

3–OMe–4–OH–C6H3

358.2 ± 6.1

7k

3,4,5–trimethoxy–C6H2

 > 750

7l

3–OPh–C6H4

453.0 ± 4.7

7m

5-Nitrobenzo[d][1,3]dioxole

353.7 ± 3.5

7n

Naphthyl

388.1 ± 6.5

7o

Thiophene

145.4 ± 5.0

Acarbose

750.0 ± 10.5

  1. aValues are the mean ± SEM. All experiments were performed at least three times
  2. bAccording to the ANOVA test followed by Tukey post hoc, all derivatives exhibited significant differences (p-value < 0.05) compared to other compounds except 7a vs 7o, 7d vs 7i, 7g vs 7h, and 7j vs 7n