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Table 3 Optimization of the solvent and temperature in room temperature or reflux condition

From: New solid phase methodology for the synthesis of biscoumarin derivatives: experimental and in silico approaches

Entry

Solvent

T (°C)

Time (min)

Yield (%)a

1

CH3CN

r.t

120

30

2

CH3CN

Reflux

120

50

3

CH2Cl2

r.t

120

40

4

CH2Cl2

Reflux

120

55

5

EtOH

r.t

120

60

6

EtOH

Reflux

120

68

7

H2O

r.t

120

70

8

H2O

Reflux

120

77

9

EtOH/H2O

r.t

120

80

10

EtOH/H2O

Reflux

120

91

11

MeOH

r.t

120

70

12

MeOH

Reflux

120

72

  1. aIsolated yield
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BMC Chemistry

ISSN: 2661-801X

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