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Table 1 Optimization of the solvent-free reaction

From: New solid phase methodology for the synthesis of biscoumarin derivatives: experimental and in silico approaches

Entry

Catalyst (mol%)

Time (min)

Yield (%)a

1

-

60

5

2

H2SO4 (15)

35

60

3

CF3CO2H(10)

50

40

4

CCl3CO2H (10)

50

55

5

PTSA(10)

50

45

6

AlCl3(10)

50

60

7

MoO3(10)

20

93

8

MoO3(11)

20

93

9

MoO3(12)

20

93

10

MoO3(8)

20

75

11

MoO3(4)

20

70

  1. aIsolated yield