Skip to main content

Table 3 SwissADME results of compounds derived from N-acylhydrazones

From: Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives

Compounds MW < 500 HA < 10 HD < 5 Log P < 5 TPSA < 140 Å Caco-2 (cm/s) LR  < 9 Log S > − 5
AH3 285.25 5 2 1.63 107.51 0.55 5 − 3.61
AH4 256.26 4 3 1.18 81.92 0.55 4 − 2.80
AH5 359.38 4 3 2.5 90.79 0.55 7 − 4.18
Chloroquine 305.85 2 1 3.68 28.16 0.56 8 − 4.21
Artemether 298.37 5 0 3.19 46.15 0.55 1 − 3.85
  1. MW molecular weight, HA hydrogen bond acceptors, HD hydrogen bond donors, log P partition coefficient, TPSA polar topological surface area, Caco-2 Human Colon Carcinoma Cell Line, LR rotating bond, Log S solubility