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Scheme 2 | BMC Chemistry

Scheme 2

From: Synthesis of novel isoxazole–carboxamide derivatives as promising agents for melanoma and targeted nano-emulgel conjugate for improved cellular permeability

Scheme 2

Compound 1 was deprotonated by the EDC in the first step, in the second step a nucleophilic attack was done, after that no acidic proton is present in the intermediate, and this makes the aniline derivatives able to make it is attacked easily, in the fourth step carbodiimide is leaving as good leaving group, and finally two compounds are observed the desired product (2a–2f) and the urea side product

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