Table 2 Interacted amino acid residues of proteins with Mangiferin
From: In-silico and in-vitro studies on the efficacy of mangiferin against colorectal cancer
Protein receptors | Interacting amino acid residue(S) |
|---|---|
APC | ASN627 (2), HIS672 (2), THR628, SER172, LEU629 (2), GLU633, TYR175 (2), TRP242 (2) |
BUBR1 | SER201, THR204, ASP172 (3), GLN176, ARG169 (4) |
CDK8 | TRP6 (2), ARG157 (3), TYR162, GLN161, PRO158 (2), PHE195 (3) |
CK2α | LEU45 (4), ASN118 (2), SER51, HIS160 (2), VAL53 (3) |
FABP6 | GLN52 (2), TYR98, SER113, ARG122 (2), GLU111, MET75 (2) |
K-Ras | GLY15 (3), LYS16, SER17, TYR32 (2), ASN116, PRO34, LYS147, LYS117 (4), PHE28, ALA18 (2) |
Spindle assembly checkpoint protein human MAD2 | ALA112, ASP76, CYS81, VAL83, LYS80, SER82, ALA19 (2), TYR79 (2), VAL22, CYS108 |
BCL-xL | PHE105 (2), ARG139, GLU129, ARG103 (2), ASP133, TYR101 (2), ALA142 |
Bcl-2 | LEU59 (2), SER60 (2), GLU136, GLU61, VAL133 (2), LYS58 (3) |
COX-2 | ASN34 (2), PRO154, CYS47 (3), CYS36 (2), ARG44 (2), GLY135, PRO153 (3) |
CYTOCHROME P450 | ASN217 (2), VAL292, ASP293, LEU208 (2), PHE114 (2), ALA103 (2) |
PROTEIN KINASE B | LYS14 (2), THR21 (2), ASN53, ILE19, GLU17 |
TNFα | ASN92, GLN125, LEU93 |
LEUKOTRIENE A4 HYDROLASE | ARG563 (2), LYS565 (2), GLU501, ASN341 (2), GLU296, VAL292 |
NF-Ò›B | HIS405, SER471, ASN403, LEU467 (2), SER471, ILE493, ALA497 (3) |