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Table 2 Interacted amino acid residues of proteins with Mangiferin

From: In-silico and in-vitro studies on the efficacy of mangiferin against colorectal cancer

Protein receptors Interacting amino acid residue(S)
APC ASN627 (2), HIS672 (2), THR628, SER172, LEU629 (2), GLU633, TYR175 (2), TRP242 (2)
BUBR1 SER201, THR204, ASP172 (3), GLN176, ARG169 (4)
CDK8 TRP6 (2), ARG157 (3), TYR162, GLN161, PRO158 (2), PHE195 (3)
CK2α LEU45 (4), ASN118 (2), SER51, HIS160 (2), VAL53 (3)
FABP6 GLN52 (2), TYR98, SER113, ARG122 (2), GLU111, MET75 (2)
K-Ras GLY15 (3), LYS16, SER17, TYR32 (2), ASN116, PRO34, LYS147, LYS117 (4), PHE28, ALA18 (2)
Spindle assembly checkpoint protein human MAD2 ALA112, ASP76, CYS81, VAL83, LYS80, SER82, ALA19 (2), TYR79 (2), VAL22, CYS108
BCL-xL PHE105 (2), ARG139, GLU129, ARG103 (2), ASP133, TYR101 (2), ALA142
Bcl-2 LEU59 (2), SER60 (2), GLU136, GLU61, VAL133 (2), LYS58 (3)
COX-2 ASN34 (2), PRO154, CYS47 (3), CYS36 (2), ARG44 (2), GLY135, PRO153 (3)
CYTOCHROME P450 ASN217 (2), VAL292, ASP293, LEU208 (2), PHE114 (2), ALA103 (2)
PROTEIN KINASE B LYS14 (2), THR21 (2), ASN53, ILE19, GLU17
TNFα ASN92, GLN125, LEU93
LEUKOTRIENE A4 HYDROLASE ARG563 (2), LYS565 (2), GLU501, ASN341 (2), GLU296, VAL292
NF-қB HIS405, SER471, ASN403, LEU467 (2), SER471, ILE493, ALA497 (3)