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Table 2 Interacted amino acid residues of proteins with Mangiferin

From: In-silico and in-vitro studies on the efficacy of mangiferin against colorectal cancer

Protein receptors

Interacting amino acid residue(S)

APC

ASN627 (2), HIS672 (2), THR628, SER172, LEU629 (2), GLU633, TYR175 (2), TRP242 (2)

BUBR1

SER201, THR204, ASP172 (3), GLN176, ARG169 (4)

CDK8

TRP6 (2), ARG157 (3), TYR162, GLN161, PRO158 (2), PHE195 (3)

CK2α

LEU45 (4), ASN118 (2), SER51, HIS160 (2), VAL53 (3)

FABP6

GLN52 (2), TYR98, SER113, ARG122 (2), GLU111, MET75 (2)

K-Ras

GLY15 (3), LYS16, SER17, TYR32 (2), ASN116, PRO34, LYS147, LYS117 (4), PHE28, ALA18 (2)

Spindle assembly checkpoint protein human MAD2

ALA112, ASP76, CYS81, VAL83, LYS80, SER82, ALA19 (2), TYR79 (2), VAL22, CYS108

BCL-xL

PHE105 (2), ARG139, GLU129, ARG103 (2), ASP133, TYR101 (2), ALA142

Bcl-2

LEU59 (2), SER60 (2), GLU136, GLU61, VAL133 (2), LYS58 (3)

COX-2

ASN34 (2), PRO154, CYS47 (3), CYS36 (2), ARG44 (2), GLY135, PRO153 (3)

CYTOCHROME P450

ASN217 (2), VAL292, ASP293, LEU208 (2), PHE114 (2), ALA103 (2)

PROTEIN KINASE B

LYS14 (2), THR21 (2), ASN53, ILE19, GLU17

TNFα

ASN92, GLN125, LEU93

LEUKOTRIENE A4 HYDROLASE

ARG563 (2), LYS565 (2), GLU501, ASN341 (2), GLU296, VAL292

NF-қB

HIS405, SER471, ASN403, LEU467 (2), SER471, ILE493, ALA497 (3)