Synthesis, antiplasmodial activity and in silico molecular docking study of pinocembrin and its analogs

BMC Chemistry

Table 2 Effect of pinocembrin and its analogs on PCV of P. berghei infected mice

No.	Dose	PCV ± SME		% Change	P value
No.	Dose	D 0	D 4	% Change	P value
6a	NC	51.11 ± 0.63	48.47 ± 0.42	− 5.16	0.01
	15	51.25 ± 0.21	50.83 ± 0.52	− 0.82	0.10
	25	51.13 ± 0.15	49.93 ± 0.41	− 2.35	0.06
	30	51.02 ± 0.13	50.04 ± 0.31	− 1.92	0.10
	35	50.75 ± 0.24	50.55 ± 0.32	− 0.40	0.30
6b	NC	51.38 ± 0.25	48.76 ± 0.40	− 5.10	0.01
6b	20	51.20 ± 0.20	50.19 ± 0.27	− 2.00	0.08
6c	NC	51.11 ± 0.63	48.47 ± 0.42	− 5.16	0.01
6c	20	50.84 ± 0.40	51.00 ± 0.31	0.32	0.31
6d	NC	51.38 ± 0.25	48.76 ± 0.31	− 5.10	0.01
6d	30	51.16 ± 0.35	49.79 ± 0.40	− 2.67	0.04
6i	NC	51.38 ± 0.31	47.98 ± 0.56	− 6.62	0.00
	15	51.09 ± 0.19	49.89 ± 0.24	− 2.35	0.06
	25	50.78 ± 0.29	50.00 ± 0.35	− 1.54	0.10
	35	51.26 ± 0.21	51.09 ± 0.23	− 0.33	0.37
7a	NC	50.98 ± 0.64	49.68 ± 0.20	− 2.55	0.04
	20	50.38 ± 0.40	50.66 ± 0.45	0.56	0.21
	30	50.76 ± 0.16	51.00 ± 0.12	0.47	0.30

ISSN: 2661-801X