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Table 1 Antibacterial activities of compounds 7–31 and ampicillin against selected Gram-positive strains (MICs in µg ml−1)

From: Synthesis of new 2-(5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one derivatives as anti-MRSA and anti-H. pylori agents

Compound

R

S. aureus

MRSA

S. epidermidis

M. luteus

B. subitilis

B. cereus

E. faecalis

7

Phenyl

0.02

3.125

0.09

25

0.78

0.39

6.25

8

4-methylphenyl

0.02

1.56

0.04

6.25

0.39

0.19

6.25

9

4-methoxyphenyl

0.04

25

0.09

50

1.56

0.78

25

10

4-methylthiophenyl

0.39

6.25

0.78

12.5

3.125

3.125

12.5

11

2-bromophenyl

0.78

6.25

1.56

25

6.25

3.125

12.5

12

3-bromophenyl

0.78

6.25

1.56

50

6.25

3.125

12.5

13

4-bromophenyl

6.25

25

3.125

100

12.5

6.25

50

14

2-chlorophenyl

0.78

6.25

1.56

25

3.125

1.56

12.5

15

3-chlorophenyl

0.78

6.25

0.78

25

1.56

3.125

12.5

16

4-chlorophenyl

0.097

6.25

0.195

12.5

1.56

1.56

12.5

17

2,6-dichlorophenyl

0.01

1.56

0.02

6.25

0.39

0.39

0.78

18

4-fluorophenyl

0.02

3.125

0.04

12.5

0.195

0.097

6.25

19

3-hydroxyphenyl

0.195

6.25

0.195

12.5

3.125

1.56

12.5

20

4-hydroxyphenyl

0.39

12.5

0.39

25

6.25

6.25

12.5

21

2-nitrophenyl

0.78

25

0.78

100

12.5

6.25

12.5

22

3-nitrophenyl

3.125

100

1.56

200

50

50

100

23

4-nitrophenyl

50

 > 200

25

 > 200

100

100

200

24

4-(dimethylamino)phenyl

1.56

25

0.78

200

3.125

1.56

100

25

3,5-di-t-butyl-4-hydroxyphenyl

1.56

12.5

1.56

25

3.125

3.125

12.5

26

3-pyridyl

3.125

50

3.125

100

25

12.5

50

27

2-indolyl

0.39

12.5

0.78

50

6.25

6.25

25

28

2-furyl

0.01

1.56

0.02

12.5

0.097

0.097

3.125

29

5-nitro-2-furyl

0.04

1.56

0.04

12.5

0.39

0.39

3.125

30

2-thienyl

0.097

3.125

0.195

25

0.78

0.39

6.25

31

5-nitro-2-thienyl

6.25

100

6.25

 > 200

50

50

200

Ampicillin

 

0.062

32

2

0.125

0.125

32

2

  1. MIC values in bold show the highest activity