Synthesis, molecular docking, and cytotoxicity of quinazolinone and dihydroquinazolinone derivatives as cytotoxic agents

Table 1 Cancer cell growth inhibitory effect of synthesized derivatives evaluated by MTT reduction assay

Compound	R¹	R²	R³	IC₅₀ (µM) MCF-7 48 h	IC₅₀ (µM) MCF-7 72 h	IC₅₀ (µM) HCT-116 48 h	IC₅₀ (µM) HCT-116 72 h
5a	Ph	2-Me-C₆H₄	–	71.17	14.70	7.15	4.87
5b	Chloromethyl	Ph	–	101.375	76.245	59.26	37.84
5c	Cyclopropyl	Ph	–	74.92	50.40	59.24	29.15
5d	4-OMe-C₆H₄	Ph	–	28.84	24.99	39.22	17.76
5e	ⁱPropyl	Ph	–	78.95	42.74	88.71	63.33
10a	Benzyl	–	H	62.29	18.88	88.79	28.99
10b	Benzyl	–	4-F	139.4	98.45	183.9	63.99
10c	Benzyl	–	4-Cl	52.00	32.30	120.35	61.02
10d	Benzyl	–	4-Br	44.68	14.80	251.1	205.9
10e	4-F-benzyl	–	2-Me	79.14	48.75	48.21	33.28
10f	4-F-benzyl	–	4-F	41.47	16.30	40.35	10.08
DOX	–	–	–	1.33	1.08	1.66	1.20

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