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Table 6 EHS assessment of the solvents used in this work (ethyl acetate & methanol) as well as the reported one (acetonitrile)

From: A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities

Selected substance Safety Health Environment Totala
Release potential Fire/Explosion Reaction/Decomposition Acute toxicity Irritation Chronic toxicity Persistency Air Hazard Water Hazard
Acetonitrile 0.61 1.00 0.60 0.51 0.63 0.43 0.34 0.43 0.00 4.55
Ethyl acetate 0.62 1.00 0.00 0.28 0.63 0.17 0.03 0.17 0.00 2.89
Methanol 0.65 1.00 0.00 0.27 0.11 0.32 0.00 0.32 0.00 2.66
  1. aObtained by summation of nine main categories scores