A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities

Table 6 EHS assessment of the solvents used in this work (ethyl acetate & methanol) as well as the reported one (acetonitrile)

Selected substance	Safety			Health			Environment			Total^a
Selected substance	Release potential	Fire/Explosion	Reaction/Decomposition	Acute toxicity	Irritation	Chronic toxicity	Persistency	Air Hazard	Water Hazard	Total^a
Acetonitrile	0.61	1.00	0.60	0.51	0.63	0.43	0.34	0.43	0.00	4.55
Ethyl acetate	0.62	1.00	0.00	0.28	0.63	0.17	0.03	0.17	0.00	2.89
Methanol	0.65	1.00	0.00	0.27	0.11	0.32	0.00	0.32	0.00	2.66

ISSN: 2661-801X