Ophthalmic formulation | Proposed method | Manufacturer and reference methods | ||||
---|---|---|---|---|---|---|
Amount taken (µg mL−1) | % found | % found | ||||
Saflutan® (contains TFL 15 µg mL−1) | 1.5 | 98.07 | 101.71 | |||
3.0 | 99.58 | 98.13 | ||||
6.0 | 98.11 | 100.94 | ||||
X̅ ± S.D | 98.59 ± 0.86 | 100.26 ± 1.88 | ||||
t | 1.40 (2.78) | |||||
F | 4.78 (19.00) | |||||
Targotimol® (contains TIM 5 mg mL−1) | 80.0 | 101.94 | 98.90 | |||
250.0 | 99.89 | 101.36 | ||||
1000.0 | 98.03 | 99.51 | ||||
X̅ ± S.D | 99.95 ± 1.96 | 99.92 ± 1.28 | ||||
t | 0.02 (2.78) | |||||
F | 2.34 (19.00) |
Taflupro plus® (contains TFL 15 µg mL−1 and TIM 5 mg mL−1) | TFL | TIM | TFL | TIM | TFL | TIM |
1.5 | 500 | 98.11 | 98.17 | 98.02 | 100.81 | |
3.0 | 1000 | 98.11 | 98.08 | 100.98 | 98.54 | |
6.0 | 2000 | 99.16 | 99.43 | 99.81 | 100.92 | |
X̅ ± S.D | 98.46 ± 0.61 | 98.56 ± 0.75 | 99.57 ± 1.45 | 100.09 ± 1.34 | ||
t | 1.22 (2.78) | 1.73 (2.78) | ||||
F | 5.65 (19.00) | 3.19 (19.00) |