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Table 3 IC50 (μM) of some chosen synthesized compounds on colon carcinoma cells (HCT-116) and hepatocellular carcinoma cells lines (HepG-2)

From: Synthesis, screening as potential antitumor of new poly heterocyclic compounds based on pyrimidine-2-thiones

Compounds

IC50 (μM)

HCT-116

HepG-2

4a

20.88 ± 1.88

35.22 ± 2.23

6a

31.92 ± 3.67

42.63 ± 4.09

7a

42.42 ± 5.54

59.07 ± 6.01

9a

38.32 ± 4.01

56.55 ± 5.23

10a

10.72 ± 0.83

18.95 ± 1.25

13a

54.01 ± 6.09

86.33 ± 7.33

14a

26.26 ± 3.09

37.87 ± 2.46

Vinblastine standard

3.61 ± 0.43

6.26 ± 0.69

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BMC Chemistry

ISSN: 2661-801X

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