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Table 1 Evaluation of cytotoxicity of some chosen synthesized compounds against colon carcinoma cells (HCT-116)

From: Synthesis, screening as potential antitumor of new poly heterocyclic compounds based on pyrimidine-2-thiones

Sample conc. (µg ml−1)

Cell viability (%)

4a

6a

7a

9a

10a

13a

14a

Vinblastine standard

50.000

16.38

26.18

29.78

32.08

14.27

35.18

21.73

12.98

25.000

19.51

37.22

41.05

43.03

17.01

44.91

27.15

16.08

12.500

27.13

46.34

50.68

52.76

23.99

54.45

37.72

20.74

6.250

48.44

70.17

74.29

77.85

44.13

59.90

52.89

39.34

3.125

58.63

85.23

83.55

85.49

52.47

88.11

63.31

48.60

1.560

75.93

91.02

94.47

96.11

66.74

98.22

80.84

59.31

0.000 (DMSO)

100.00

100.00

100.00

100.00

100.00

100.00

100.00

100.00