Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides

BMC Chemistry

Table 1 The effect of different parameters on the reaction of 1a and 2a.^a

^aReaction conditions: All reactions were performed with 1a (0.5 mmol), 2a (1.5 equiv.), copper catalyst (10 mol%), Mn powder (3 equiv.), CF₃COOH (25 mol%), solvent (2 mL), at room temperature under N₂ atmosphere. ^b Yield was determined by GC with dodecane as internal standard based on 1a. ^c Reaction in the air. ^d Without CF₃COOH. ^e 5.0 equiv. of Mn was added. ^f CuCl (20 mol%) was added.

ISSN: 2661-801X