Skip to main content

Table 1 Optimization of the reaction conditions for the synthesis of 4-(4-chlorophenyl)-3,5-dimethyl-1,4,7,8-tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine
figure b

From: Catalyst-free synthesis of tetrahydrodipyrazolopyridines via an one-pot tandem and green pseudo-six-component reaction in water

Entry

Solvent

Conditionsa

Time (min)

Yield (%)b

1

EtOH

r.t

180

–

2

EtOH

Reflux

120

23

3

H2O

Reflux

60

53

4

H2O

r.t

45

98 [This work]

  1. aThe molar ratio of hydrazine hydrate (2 mmol), ethyl acetoacetate (2 mmol),4-chlorobenzaldehyde (1 mmol) and ammonium acetate (4 mmol) is equal to 2:2:1:4
  2. bIsolated yields
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us