Table 2 List of amino acids involved in hydrogen bonding and hydrophobic interactions with CHP4 and donepezil with AChE

CHP4

S124b

Chain b:

W84, Y121, D72, S122,

*F331, *Y334, *F330, N85

Y121b

Chain b:

W84, Y121, D72, S122, *F331, *Y334, *F330, N85

DPZ

S228b, S205b

Chain b:

F288, A234, W233, *F331, C231, S288,A204, P229, F290, N230, F120, M208, S200, I287, *F330, N399, S235, V395, L332, *Y334, V400

_

Chain b:

F288, A234, *F331, C231, S288,A204, P229, F290, N230, F120, M208, *F330, N399, S235, V395, L332, *Y334, V400