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Table 1 Drug-likeness properties of CHP1 to CHP4

From: Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells

Descriptor

CHP1

CHP2

CHP3

CHP4

CHP5

Hydrogen bond donor

1

1

2

2

1

Hydrogen bond acceptor

5

6

5

5

4

AlogP

0.027

0.054

− 0.380

− 0.380

0.82

Number of rotatable bonds

4

5

3

3

3

Polar surface area

59.4

76.47

70.4

70.4

50.17

Molecular mass

262.062

314.057

248.046

248.046

266.012

Number of atoms

29

33

26

26

25