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Table 1 Drug-likeness properties of CHP1 to CHP4

From: Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells

Descriptor CHP1 CHP2 CHP3 CHP4 CHP5
Hydrogen bond donor 1 1 2 2 1
Hydrogen bond acceptor 5 6 5 5 4
AlogP 0.027 0.054 − 0.380 − 0.380 0.82
Number of rotatable bonds 4 5 3 3 3
Polar surface area 59.4 76.47 70.4 70.4 50.17
Molecular mass 262.062 314.057 248.046 248.046 266.012
Number of atoms 29 33 26 26 25