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Table 1 Physicochemical properties and chemical structures of the selected antibiotics commonly used on poultry production [29, 30]

From: Development and validation of liquid chromatography method for simultaneous determination of multiclass seven antibiotic residues in chicken tissues

Class

Compound molecular formula and weight

Chemical structure

Solubility in water (mg/mL)

Log Kow

pKa

β-Lactams

Amoxicillin, C16H19N3O5S, 365.4 g mol−1

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3.4

0.87, 0.97

2.4, 2.8, 7.2

 

Ampicillin, C16H19N3O4S, 349.4 g mol−1

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10.1

1.45

2.53, 2.7 7.3

 

Benzylpenicillin (penicillin G), C16H18N2O4S, 334.4 g mol−1

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0.2

1.85

2.7, 2.8

Fluoro-quinolones

Ciprofloxacin C17H18FN3O3, 331.3 g mol−1

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36

0.4

3.01, 6.38, 8.70

Aminoglycoside

Gentamicin C21H43N5O7, 477.6 g mol−1

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100

-1.88

8.2

Macrolides

Erythromycin C37H67NO13, 733.9 g mol−1

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2

3.06, 2.48

8.88, 8.9

Sulfonamides

Sulfamethoxazole C10H11N3O3S, 253.3 g mol−1

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0.61

0.89, 0.48

1.85, 5.6

  1. Kow: the octanol–water partition coefficient
  2. pKa: acidity constant