Synthesis, in silico molecular docking analysis, pharmacokinetic properties and evaluation of antibacterial and antioxidant activities of fluoroquinolines

Table 5 ADME predictions of compounds computed by SwissADME and PreADMET

Compounds	Formula	Skin permeation value (log Kp) cm/s	GI absorption	BBB permeability	Inhibitor interaction (SwissADME/PreADMET)
Compounds	Formula	Skin permeation value (log Kp) cm/s	GI absorption	BBB permeability	P-gp substrate	CYP1A2	CYP2C19	CYP2C9	CYP2D6	CYP3A4
4	C₁₀H₅ClFNO	− 5.65	High	Yes	No	Yes	No	No	No	No
5	C₁₁H₈FNO₂	− 6.09	High	Yes	No	Yes	No	No	No	No
6	C₁₂H₁₀FNO₂	− 5.92	High	Yes	No	Yes	Yes	No	No	No
7	C₁₂H₆FNOS	− 5.37	High	Yes	No	Yes	Yes	No	No	No
8	C₁₀H₅ClFNO₂	− 5.7	High	Yes	No	No	No	No	No	No
9	C₁₄H₁₆FN₃O₂	− 7.42	High	No	Yes	No	No	No	No	No
10	C₂₂H₁₆FN₃	− 4.5	High	No	No	Yes	Yes	No	Yes	Yes
15	C₁₁H₉NO₂	− 6.05	High	Yes	No	Yes	No	No	No	No
16	C₁₂H₁₁NO₃	− 5.96	High	Yes	No	Yes	No	No	No	No
Vosaroxin	C₁₈H₁₉N₅O₄S	− 8.98	High	No	Yes	Yes	No	No	No	No

ISSN: 2661-801X