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Table 3 Physicochemical properties of synthetic compounds (5a–5u) according to rule of five

From: Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines

Compounds

M.W

HBA

HBD

LogP

TPSA

5a

393.13

6

2

3.62

77.71

5b

520.07

7

3

5.49

88.0

5c

349.09

4

2

4.74

54.74

5d

407.15

6

2

3.49

79.04

5e

303.10

3

2

3.93

54.74

5f

333.11

4

2

4.07

62.28

5g

363.12

5

2

4.32

69.82

5h

363.12

5

2

3.65

70.00

5i

363.12

5

2

4.01

69.21

5j

295.13

3

1

3.26

48.29

5k

297.11

4

1

2.08

56.20

5l

283.13

3

2

3.43

56.17

5m

337.06

3

2

4.71

54.74

5n

381.01

3

2

4.95

54.74

5o

318.11

4

2

2.45

65.49

5p

318.11

4

2

2.51

65.58

5q

318.11

4

2

2.68

65.60

5r

400.19

4

2

3.83

59.32

5s

440.15

3

1

4.90

51.55

5t

454.16

4

1

4.51

51.83

5u

373.15

4

1

2.81

60.98

  1. M.W. Molecular weight, HBA Hydrogen bond acceptor, HBD Hydrogen bond donor, LogP Partition coefficient, TPSA Topological polar surface area