Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study

Table 4 In silico drug-likeness predictions of synthesized compounds computed by SwissADME

Compounds	HBAs^a	HBDs^b	MR	TPSA	iLogP	Lipinski^b violations
7	4.00	2.00	85.29	93.95	2.54	–
8	2.00	0.00	81.25	53.49	3.07	–
9	5.00	1.00	92.09	119.54	2.10	–
10	4.00	0.00	90.07	99.31	2.71	–
11	6.00	0.00	98.89	145.13	2.34	–
Amoxicillin	6.00	4.00	94.59	158.26	0.95	–

^aHBAs = number of hydrogen bond acceptors
^bHBDs = number of hydrogen bond donors, MR = molar refractivity, and TPSA = topological polar surface area. Molecular weights for all the compounds are less than 400 g/mol

ISSN: 2661-801X