Table 3 Comparison with other methods for detection of residues and contaminants in meat
From: A new LC–MS/MS method for multiple residues/contaminants in bovine meat
Target compounds | Matrix | Sample preparation and clean up | Stationary phase | Tandem MS system | Most important differences in the method | LOQ ranges | References |
|---|---|---|---|---|---|---|---|
84 veterinary drugs | Muscle | Liquid extraction with ethylenediamine tetraacetic acid (EDTA-succinate buffer and acetonitrile, followed by phase separation and evaporation of the supernatant | RP-LC column (pentafluoro- phenylpropyl) | MS/MS | Different extraction solvents Sample preparation without SPE extraction Different LC column Pesticides and mycotoxins are not included | 2–48 µg/kg | [3] |
28 Pesticides, Plant Hormone, Veterinary Drugs and Mycotoxins | Food matrices (including meat) | Liquid–liquid extraction with acidified methanol with formic acid | ZIC-pHILIC | MS/MS | Different extraction solvents Sample preparation without SPE extraction Different LC column Anabolic hormones, β-agonists, lactones, some class of antibiotics and zearalenone are not included Included only 2 pesticides | 1–10 µg/kg | [5] |
More than 300 veterinary drugs and pesticides | meat, fish and vegetables as baby food samples | Liquid–liquid extraction with acetonitrile containing formic acid followed by SPE extraction (Florisil cartridge) | C18 column | Orbitrap QqQ/MS | Different extraction solvents SPE extraction with different type of cartridge Different MS detector Mycotoxins are not included | 10–100 µg/kg | [11] |
100 veterinary drugs | Muscle | Liquid extraction with EDTA-succinate buffer and acetonitrile, followed by SPE extraction (Oasis HLB, 200 mg/6 ml) | HSS-T3 | TOF | Different extraction solvents SPE extraction with different type of HLB cartridge Different LC column Different MS detector Pesticides and mycotoxins are not included | < 5 µg/kg | [12] |
41 veterinary drugs | Muscle | QuEChERS (SPE extraction with Bond Elut SCX cartridge is additional step for extraction of nitroimidazoles) | C18 column | MS/MS | Different extraction solvents SPE extraction with different type of cartridge Pesticides and mycotoxins are not included | n/a* | [17] |
128 Veterinary drugs, pesticides | Muscle | QuEChERS | C18 column | MS/MS | Different extraction solvents Sample preparation without SPE extraction Anabolic hormones, β-agonists, lactones, some class of antibiotics and mycotoxins are not included | n/a* | [19] |
130 Veterinary drugs | Muscle | liquid–liquid extraction with acetonitrile: methanol followed by delipidation with n-hexane saturated with acetonitrile | C18 column | MS/MS | Different extraction solvents Sample preparation without SPE extraction Pesticides and mycotoxins are not included | 0.1–10 µg/kg | [22] |
226 veterinary drugs, pesticides, mycotoxins | Muscle | liquid–liquid extraction (EDTA–Na2, acetonitrile–ethanol, n-hexane), purification by low temperature clean-up (− 40 °C/2 h) and dispersive solid-phase extraction (D-SPE) | HSS-T3 | MS/MS | Different extraction solvents Sample preparation without SPE extraction Different LC column Different temperature and time for low temperature clean-up (80 °C/20 min) | 0.05–10 µg/kg | [24] |