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Table 3 Comparison with other methods for detection of residues and contaminants in meat

From: A new LC–MS/MS method for multiple residues/contaminants in bovine meat

Target compounds Matrix Sample preparation and clean up Stationary phase Tandem MS system Most important differences in the method LOQ ranges References
84 veterinary drugs Muscle Liquid extraction with ethylenediamine tetraacetic acid (EDTA-succinate buffer and acetonitrile, followed by phase separation and evaporation of the supernatant RP-LC column (pentafluoro-
phenylpropyl)
MS/MS Different extraction solvents
Sample preparation without SPE extraction
Different LC column
Pesticides and mycotoxins are not included
2–48 µg/kg [3]
28 Pesticides, Plant Hormone, Veterinary Drugs and Mycotoxins Food matrices (including meat) Liquid–liquid extraction with acidified methanol with formic acid ZIC-pHILIC MS/MS Different extraction solvents
Sample preparation without SPE extraction
Different LC column
Anabolic hormones, β-agonists, lactones, some class of antibiotics and
zearalenone are not included
Included only 2 pesticides
1–10 µg/kg [5]
More than 300 veterinary drugs and pesticides meat, fish and vegetables as baby food samples Liquid–liquid extraction with acetonitrile containing formic acid followed by SPE extraction (Florisil cartridge) C18 column Orbitrap
QqQ/MS
Different extraction solvents
SPE extraction with different type of cartridge
Different MS detector
Mycotoxins are not included
10–100 µg/kg [11]
100 veterinary drugs Muscle Liquid extraction with EDTA-succinate buffer and acetonitrile, followed by SPE extraction (Oasis HLB, 200 mg/6 ml) HSS-T3 TOF Different extraction solvents
SPE extraction with different type of HLB cartridge
Different LC column
Different MS detector
Pesticides and mycotoxins are not included
< 5 µg/kg [12]
41 veterinary drugs Muscle QuEChERS (SPE extraction with Bond
Elut SCX cartridge is additional step for extraction of nitroimidazoles)
C18 column MS/MS Different extraction solvents
SPE extraction with different type of cartridge
Pesticides and mycotoxins are not included
n/a* [17]
128 Veterinary drugs, pesticides Muscle QuEChERS C18 column MS/MS Different extraction solvents
Sample preparation without SPE extraction
Anabolic hormones, β-agonists, lactones, some class of antibiotics and mycotoxins are not included
n/a* [19]
130 Veterinary drugs Muscle liquid–liquid extraction with acetonitrile: methanol followed by delipidation with n-hexane saturated with acetonitrile C18 column MS/MS Different extraction solvents
Sample preparation without SPE extraction
Pesticides and mycotoxins are not included
0.1–10 µg/kg [22]
226 veterinary drugs, pesticides, mycotoxins Muscle liquid–liquid extraction (EDTA–Na2, acetonitrile–ethanol, n-hexane), purification by low temperature clean-up (− 40 °C/2 h) and dispersive solid-phase extraction (D-SPE) HSS-T3 MS/MS Different extraction solvents
Sample preparation without SPE extraction
Different LC column
Different temperature and time for low temperature clean-up (80 °C/20 min)
0.05–10 µg/kg [24]
  1. *n/a not applicable