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Table 4 Log CFU/ml values of the selected compound 1 in Aloe vera juice and White lotion USP

From: Aesculin based glucosamine-6-phosphate synthase inhibitors as novel preservatives for food and pharmaceutical products: in-silico studies, antioxidant, antimicrobial and preservative efficacy evaluation

Compound

E. coli

P. aeruginosa

S. aureus

C. albicans

A. niger

Cfu/ml after days

14 days

28 days

14 days

28 days

14 days

28 days

14 days

28 days

14 days

28 days

Compound 1

#

2.75 ± 0.01a

2.21 ± 0.02b

2.51 ± 0.03c

2.21 ± 0.04d

2.22 ± 0.06e

2.62 ± 0.06f

2.11 ± 0.08 g

2.54 ± 0.02 h

2.50 ± 0.04i

2.80 ± 0.04j

@

2.23 ± 0.01a

2.42 ± 0.03b

2.31 ± 0.04c

2.53 ± 0.03d

2.21 ± 0.04e

2.61 ± 0.03f

2.15 ± 0.06 g

2.06 ± 0.01 h

2.12 ± 0.02i

2.60 ± 0.02j

Sodium benzoate

#

2.23 ± 0.01a

2.21 ± 0.01b

2.22 ± 0.01c

2.21 ± 0.02d

2.83 ± 0.01e

2.16 ± 0.01f

2.06 ± 0.02 g

2.80 ± 0.02 h

2.16 ± 0.02i

2.30 ± 0.01j

@

3.23 ± 0.01a

3.33 ± 0.24b

3.22 ± 0.16c

3.21 ± 0.03d

3.83 ± 0.04e

3.16 ± 0.04f

3.07 ± 0.08 g

2.80 ± 0.08 h

3.16 ± 0.01i

3.32 ± 0.01j

Propyl paraben

#

2.20 ± 0.01a

2.26 ± 0.06b

2.31 ± 0.01c

2.36 ± 0.02d

2.83 ± 0.02e

2.56 ± 0.01f

2.40 ± 0.01 g

2.50 ± 0.01 h

2.13 ± 0.05i

2.04 ± 0.02j

@

3.20 ± 0.57a

3.24 ± 0.36b

3.31 ± 0.01c

3.30 ± 0.01d

3.83 ± 0.02e

3.56 ± 0.01f

3.90 ± 0.02 g

3.53 ± 0.01 h

3.13 ± 0.06i

3.43 ± 0.01j

Ethyl Paraben

#

2.31 ± 0.03a

2.04 ± 0.18b

2.22 ± 0.16c

2.30 ± 0.11d

2.11 ± 0.04e

2.20 ± 0.01f

2.52 ± 0.02 g

2.20 ± 0.02 h

2.03 ± 0.02i

2.30 ± 0.05j

@

3.36 ± 0.02a

3.00 ± 0.14b

3.24 ± 0.36c

3.34 ± 0.01d

3.16 ± 0.04e

3.10 ± 0.02f

3.50 ± 0.01 g

3.20 ± 0.01 h

3.03 ± 0.04i

3.30 ± 0.08j

  1. Initial microbial count present in inoculums 1 × 105–1 × 106; # Aloe vera juice; @ White lotion USP
  2. CFU = Colony forming unit, all experiments were conducted in triplicate (n = 3) and the mean values are presented. Different letters mean p < 0.05 in each line by One-way ANOVA test