Structure | Compound code | R1 | R2 | R3 | IC50 (µg/ml) | |
---|---|---|---|---|---|---|
α-amylase | Lipase | |||||
| 3a | Cl | H | H | 2.52 ± 1.1 | 145.49 ± 2.5 |
3b | H | H | H | 61.45 ± 1.5 | > 400 | |
3c | I | H | H | 39.85 ± 1.3 | > 400 | |
3d | H | I | H | 16.36 ± 0.75 | 118.86 ± 2.1 | |
3e | Br | H | H | 2.57 ± 0.90 | 78.37 ± 1.72 | |
3f | H | Br | H | 9.29 ± 1.4 | > 400 | |
3 g | Cl | H | Cl | 3.94 ± 2.01 | > 400 | |
| 4a | Cl | H | H | 8.88 ± 2.10 | > 400 |
4b | H | Cl | H | 1.25 ± 1.01 | > 400 | |
4c | H | H | H | 4.12 ± 1.63 | 213.82 ± 2.1 | |
4d | I | H | H | 7.95 ± 1.15 | 187.7 ± 1.23 | |
4e | H | I | H | 3.85 ± 0.98 | 201.2 ± 2.37 | |
4f | Br | H | H | 1.11 ± 1.07 | 290.7 ± 2.23 | |
4 g | H | Br | H | 4.90 ± 2.21 | 225.8 ± 1.43 | |
4 h | Cl | H | Cl | 9.50 ± 0.56 | 206.6 ± 1.96 | |
| 6a | O–CH3 | O–CH3 | H | 8.547 ± 1.55 | 44.47 ± 2.30 |
6b | O–CH3 | H | O–CH3 | 4.286 ± 1.01 | 100.8 ± 1.73 | |
Acarbose | 6.47 ± 2.01 | - | ||||
Orlistat | – | 25.01 ± 1.71 |