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Table 1 All chemical structures of evaluated compounds and their IC50 values regarding α-amylase and lipase inhibitory activities

From: Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives

Structure

Compound code

R1

R2

R3

IC50 (µg/ml)

α-amylase

Lipase

3a

Cl

H

H

2.52 ± 1.1

145.49 ± 2.5

3b

H

H

H

61.45 ± 1.5

> 400

3c

I

H

H

39.85 ± 1.3

> 400

3d

H

I

H

16.36 ± 0.75

118.86 ± 2.1

3e

Br

H

H

2.57 ± 0.90

78.37 ± 1.72

3f

H

Br

H

9.29 ± 1.4

> 400

3 g

Cl

H

Cl

3.94 ± 2.01

> 400

4a

Cl

H

H

8.88 ± 2.10

> 400

4b

H

Cl

H

1.25 ± 1.01

> 400

4c

H

H

H

4.12 ± 1.63

213.82 ± 2.1

4d

I

H

H

7.95 ± 1.15

187.7 ± 1.23

4e

H

I

H

3.85 ± 0.98

201.2 ± 2.37

4f

Br

H

H

1.11 ± 1.07

290.7 ± 2.23

4 g

H

Br

H

4.90 ± 2.21

225.8 ± 1.43

4 h

Cl

H

Cl

9.50 ± 0.56

206.6 ± 1.96

6a

O–CH3

O–CH3

H

8.547 ± 1.55

44.47 ± 2.30

6b

O–CH3

H

O–CH3

4.286 ± 1.01

100.8 ± 1.73

Acarbose

    

6.47 ± 2.01

-

Orlistat

    

25.01 ± 1.71