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Table 5 Effects of different instruments, columns, column temperatures, flow rates, volume and pH on RRTs (n = 3)

From: Simultaneous determination of five diuretic drugs using quantitative analysis of multiple components by a single marker

Effects Factor Torasemide Furosemide Azosemide Etacrynic acid Bumetanide
RSD%
 Chromatographic Columns 38.95 36.77 35.97 - 31.67
 HPLC Instruments 1.09 1.24 3.38 - 2.34
 Column Temperatures 1.58 1.36 0.54 - 0.93
 Flow Volume of Mobile Phase 2.10 2.11 0.93 - 1.22
 Flow Rate of Mobile Phase 1.22 0.75 0.40 - 0.005
 pH Value of Mobile Phase 4.87 3.21 3.99 - 3.71
 \(\bar \chi \) 0.31 0.49 0.63 - 2.11
 S 0.001 0.001 0.001 - 0.009
 \(\bar \chi \pm 3{\rm{S}}\) 0.31 ± 0.003 0.49 ± 0.004 0.63 ± 0.002 - 2.11 ± 0.028