|
---|
Entry
|
Conditions
|
Time (min)
|
Yielda (%)
|
---|
Solvent/temp (°C)/catalyst (g)
|
---|
1
|
H2O/EtOH (1:1)/60/‒
|
180
|
28
|
2
|
H2O/60/0.03
|
30
|
70
|
3
|
EtOH/60/0.03
|
30
|
58
|
4
|
CHCl3/60/0.03
|
60
|
50
|
5
|
MeOH/60/0.03
|
60
|
70
|
6
|
‒/60/0.03
|
120
|
42
|
7
|
‒/80/0.03
|
90
|
58
|
8
|
H2O/EtOH (1:1)/r.t/0.03
|
15
|
10
|
9
|
H2O/EtOH (1:1)/40/0.03
|
15
|
58
|
10
|
H2O/EtOH (1:1)/60/0.03b
|
15
|
92
|
11
|
H2O/EtOH (1:1)/60/0.01
|
50
|
76
|
12
|
H2O/EtOH (1:1)/60/0.02
|
30
|
80
|
13
|
H2O/EtOH (1:1)/60/0.04
|
20
|
92
|
14
|
H2O/EtOH (1:1)/60/0.05
|
35
|
70
|
- Reaction conditions: malononitrile (1 mmol), 4-chlorobenzaldehyde (1 mmol), dimedone (1 mmol) and nano-SiO2/DBN as catalyst
- aIsolated yield
- bThe modified condition