Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5

Table 7 ADME predictions of compounds 1–5, computed by SwissADME and PreADMET

Cpds	Formula	Skin Permeation Value (log Kp) cm/s	GI Absorption	BBB Permeability	Inhibitor Interaction (SwissADME/PreADMET)
Cpds	Formula	Skin Permeation Value (log Kp) cm/s	GI Absorption	BBB Permeability	P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1	C₄₆H₆₆O₆	− 3.96	Low	No	Yes	No	No	No	No	No
2	C₂₂H₃₀O₄	− 7.25	High	Yes	Yes	No	No	No	No	No
3	C₁₄H₂₈O₂	− 3.35	High	Yes	No	Yes	No	No	No	No
4	C₂₉H₄₈O	− 2.24	Low	No	No	No	No	Yes	No	No
5	C₂₉H₄₈O	− 2.92	Low	No	No	No	No	No	No	No
5	Ciprofloxacin	− 8.98	High	No	Yes	Yes	No	No	No	No

GI: Gastro-Intestinal; BBB: Blood Brain Barrier; P-gp: P-glycoprotein; CYP: Cytochrome-P

ISSN: 2661-801X