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Table 7 ADME predictions of compounds 1–5, computed by SwissADME and PreADMET

From: Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5

Cpds Formula Skin Permeation Value (log Kp) cm/s GI Absorption BBB Permeability Inhibitor Interaction (SwissADME/PreADMET)
P-gp substrate CYP1A2 inhibitor CYP2C19 inhibitor CYP2C9 inhibitor CYP2D6 inhibitor CYP3A4 inhibitor
1 C46H66O6 − 3.96 Low No Yes No No No No No
2 C22H30O4 − 7.25 High Yes Yes No No No No No
3 C14H28O2 − 3.35 High Yes No Yes No No No No
4 C29H48O − 2.24 Low No No No No Yes No No
5 C29H48O − 2.92 Low No No No No No No No
Ciprofloxacin − 8.98 High No Yes Yes No No No No
  1. GI: Gastro-Intestinal; BBB: Blood Brain Barrier; P-gp: P-glycoprotein; CYP: Cytochrome-P