Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents

Table 1 Anticancer activity of newly synthesized compounds 7a–j with IC₅₀ in µM

Compound	MCF-7	A549	DU-145	MDA MB-231
7a	0.76 ± 0.044	0.18 ± 0.019	1.13 ± 0.55	0.93 ± 0.013
7b	0.011 ± 0.009	0.053 ± 0.0071	0.017 ± 0.0062	0.021 ± 0.0028
7c	0.88 ± 0.073	1.44 ± 0.32	1.28 ± 0.27	1.95 ± 0.19
7d	1.78 ± 0.22	1.67 ± 0.49	2.10 ± 1.09	2.34 ± 1.10
7e	3.45 ± 1.87	6.34 ± 3.24	ND	3.98 ± 1.88
7f	5.98 ± 2.56	ND	6.22 ± 2.91	ND
7g	9.22 ± 5.66	10.5 ± 5.72	4.33 ± 4.25	2.75 ± 1.24
7h	8.21 ± 5.19	11.3 ± 6.32	ND	ND
7i	2.17 ± 1.66	1.88 ± 0.25	2.65 ± 1.26	2.14 ± 0.94
7j	7.12 ± 4.30	13.6 ± 7.56	ND	19.4 ± 8.11
Etoposide	2.11 ± 0.024	3.08 ± 0.135	1.97 ± 0.45	1.91 ± 0.84

ISSN: 2661-801X