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Table 3. Optimization of reaction temperature and time

From: The development of an effective synthetic route of rilpivirine

Temperature (°C) Time (min) Yield (%)
120 60 48
120 90 51
120 120 56
130 60 52
130 90 60
130 120 65
140 60 60
140 90 71
140 120 71.4
150 60 65
150 90 71.2
150 120 70