Table 3. Optimization of reaction temperature and time
From: The development of an effective synthetic route of rilpivirine
Temperature (°C) | Time (min) | Yield (%) |
|---|---|---|
120 | 60 | 48 |
120 | 90 | 51 |
120 | 120 | 56 |
130 | 60 | 52 |
130 | 90 | 60 |
130 | 120 | 65 |
140 | 60 | 60 |
140 | 90 | 71 |
140 | 120 | 71.4 |
150 | 60 | 65 |
150 | 90 | 71.2 |
150 | 120 | 70 |