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Table 2. Optimization of solvent for the synthesis of rilpivirine with better yield

From: The development of an effective synthetic route of rilpivirine

Solvents Method Temperature (°C) Time Yield%
Dioxane A 90 12 h 0
CH3CN A reflux 69 h 69
NMP A 90 16 h 75
Dioxane B 100 30 min 0
CH3CN B 100 60 min 40
NMP B 100 60 min 43
  1. Method A Under atmospheric pressure, Method B Microwave-assisted synthesis