Table 2. Optimization of solvent for the synthesis of rilpivirine with better yield
From: The development of an effective synthetic route of rilpivirine
Solvents | Method | Temperature (°C) | Time | Yield% |
|---|---|---|---|---|
Dioxane | A | 90 | 12 h | 0 |
CH3CN | A | reflux | 69 h | 69 |
NMP | A | 90 | 16 h | 75 |
Dioxane | B | 100 | 30 min | 0 |
CH3CN | B | 100 | 60 min | 40 |
NMP | B | 100 | 60 min | 43 |