Scheme 3.From: The development of an effective synthetic route of rilpivirineSynthesis of intermediate 3 from 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (10) as starting material [15,16,17]. Reagents and conditions: (i) CH3I, NaOH, r.t., overnight, 88%; (iia) DME, reflux, 18 h, 68%; (iib) 180–190 °C, 10 h, 70–74%; (iic) 180 °C, 8 h, 73.6% (iii) POCl3, reflux, 20 min, 77%Back to article page
