Scheme 2.From: The development of an effective synthetic route of rilpivirineSynthesis of intermediate 2 from 4-iodo-2,6-dimethylaniline (8) and acrylonitrile (9) as starting materials [13]. Reagents and conditions: (i) CH3COONa, Pd/C, DMAC, N2, 140 °C, 21 h, 81%; (ii) EtOH, HCl, 2-propanol, 60 °C, 1 h, 64.5%Back to article page