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Scheme 1. | BMC Chemistry

Scheme 1.

From: The development of an effective synthetic route of rilpivirine

Scheme 1.

Synthesis of intermediate 2 from 5-bromo-2,4,6-trichloropyrimidine (4) and acrylamide (5) as starting materials [11]. Reagents and conditions: (i) Pd(OAc)2, P(C6H5CH3)3, Et3N, CH3CN, N2, 79 °C, overnight, 79.5%; (ii) POCl3, 0 °C, 30 min; 20 °C, overnight, 84%; (iii) EtOH, ((CH3)2CH2)2O, N2, 60 °C, 30 min; HCl, 2-propanol, 60 °C, 30 min, 77%

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